` Mural Oncology: Immuno Oncology Quiz
Test Your
IO IQ
How Is Your
Immuno-Oncology
Knowledge?

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Answer questions and you will see
how you did on this quiz

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 1
Cytokines are proteins integral to the functioning
of the immune system.
Correct Incorrect
The correct answer is True
The cytokine superfamily of proteins is an integral
part of the signaling network between cells and is
essential in generating and regulating the immune
system. Cytokines influence growth and
development, hematopoiesis, lymphocyte
recruitment, T-cell subset differentiation,
inflammation, and anti-tumor effects. Hundreds
of cytokines have been identified.
Next

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 2
Interleukins (ILs) are:
Correct Incorrect
The correct answer is A
Interleukins (ILs) are a type of cytokine originally
believed to be expressed only by leukocytes, but
have been subsequently found to be produced by
many other cell types. They play essential roles in
the activation and differentiation of immune cells,
as well as proliferation, maturation, migration, and
adhesion. They also have pro-inflammatory and
anti-inflammatory properties as well as
anti-tumor effects.
Next

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 3

Interleukin-2 (IL-2) stimulates the
expansion of cytotoxic CD8+ T cells via
the intermediate-affinity 2-chain (β,γ) receptor.

Correct Incorrect
The correct answer is True

Interleukin-2 (IL-2) can stimulate the expansion
and activation of CD8+ T cells and natural
killer (NK) cells.

In addition, IL-2 can expand and activate regulatory
T (Treg) cells via the high-affinity 3-chain IL-2 receptor.

Next

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© 2023 Mural Oncology, plc. All rights reserved.

Question 4

Interleukin-2 (IL-2) is a cytokine whose action
is mediated via:

Correct Incorrect
The correct answer is C

Interleukin-2 (IL-2) is a cytokine that binds various immune cells
via the IL-2 receptor.
IL-2 binds to both the intermediate-affinity IL-2 receptor that is made up
of 2 chains (β subunit and γ subunit), and the high-affinity IL-2 receptor
that is made up of 3 chains (α subunit, β subunit, and γ subunit).

The type of IL-2 receptor expressed on the cell
surface is dependent on the type of immune cell.

Next

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© 2023 Mural Oncology, plc. All rights reserved.

Question 5

Interleukin-2 (IL-2) receptors (either intermediate-affinity
or high-affinity) are found on various types of
immune cells including:

Correct Incorrect
The correct answer is A

Interleukin-2 (IL-2) receptors are found on several immune cell types including
anti-tumor CD8+ T cells and natural killer (NK) cells, as well as,
immunosuppressive regulatory T cells (Treg).

CD8+ T cells and NK cells generally express the intermediate-affinity
2-chain form of the receptor, whereas Tregs generally express the
high-affinity 3-chain receptor.

Next

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© 2023 Mural Oncology, plc. All rights reserved.

Question 6

Which of the following about the tumor effects of interleukin-2 (IL-2) is correct:

Correct Incorrect
The correct answer is C

Interleukin-2 (IL-2) is a cytokine that can both stimulate and
suppress the anti-tumor effects of the immune system. This is
mediated by the type of receptor and the immune cell type that
binds IL-2. Tumors leverage the immunosuppressive effects of IL-2
mediated by the regulatory T cells, which express the high-affinity
3-chain (α, β, γ) IL-2 receptor.

In contrast, stimulating the activation and expansion of cytotoxic
CD8+ T cells and natural killer cells via the intermediate-affinity
2-chain (β, γ) IL-2 receptor, results in anti-tumor effects mediated
by these immune cells.

Next

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 7

Which of the following cells are associated with cytotoxic
anti-tumor effects?

Correct Incorrect
The correct answer is C

Cytotoxic CD8+ T cells and natural killer (NK) cells
have anti-tumor effects.

In contrast, regulatory T (Treg) cells suppress the
anti-tumor effects of the immune system.

Next

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© 2023 Mural Oncology, plc. All rights reserved.

Question 8

Drag the immune cell labels onto the correct
blue tile based on their role in cancer.

NK Cell
Treg Cell
CD8+ T Cell
Anti-tumor effects
Drag immune cell label(s) here
Not sure
Drag immune cell label(s) here
Tumor evasion effects
Drag immune cell label(s) here
NK Cell
Treg Cell
CD8+ T Cell

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 9

Drag and drop the cells onto the correct images based on the
type of interleukin-2 (IL-2) receptor they predominantly express.

NK Cell
Treg Cell
CD8+ T Cell
Drag immune cell label(s) here
Drag immune cell label(s) here
NK Cell
Treg Cell
CD8+ T Cell

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© 2023 Mural Oncology, plc. All rights reserved.

Question 10

Match the correct statements:
Select a blue tile and a matching green tile to correctly complete the statement

Binding of IL-2 to the intermediate-affinity 2-chain IL-2 receptor
Binding of IL-2 to the high-affinity 3-chain
IL-2 receptor
would be expected to stimulate the anti-tumor effects of IL-2
would be expected to inhibit the anti-tumor effects of IL-2
Binding of IL-2 to the intermediate-affinity 2-chain IL-2 receptor
Binding of IL-2 to the high-affinity 3-chain
IL-2 receptor

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© 2023 Mural Oncology, plc. All rights reserved.

Question 11

Identify where IL-2 and PD-1/PD-L1 pathways
play a role in the cancer immunity cycle.

Select 2 stages to answer

Release of cancer cell antigens
1
Cancer antigen
presentation
2
Priming
and activation
3
Trafficking of
T cells to tumors
4
Infiltration of T cells
into tumors
5
Recognition of
cancer cells by T cells
6
Killing of cancer cells
7

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 12

Which of the following cell types are
associated with immunosuppressive effects?

Correct Incorrect
The correct answer is B

Regulatory T (Treg) cells monitor and inhibit
the activity of other T cells.

In contrast, cytotoxic CD8+ T cells and natural killer (NK) cells
are crucial for recognizing and removing cancer cells.

Next

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 13

Antigen-presenting cells (APCs) are a heterogeneous group
of immune cells that mediate the cellular immune response by:

Correct Incorrect
The correct answer is B

Antigen-presenting cells are responsible for
processing large molecules into “readable”
fragments (antigens) for recognition by T cells.

Next

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© 2023 Mural Oncology, plc. All rights reserved.

Question 14

What are the three main types of antigen-presenting cells?

Correct Incorrect
The correct answer is A

Dendritic cells, B cells and macrophages are the
three main types of antigen-presenting cells.

CD8+ T cells and natural killer (NK) cells play key
roles in recognizing and removing cancer cells and
regulatory T (Treg) cells monitor and inhibit the
activity of other T cells.

Next

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 15

Match the cytotoxic effector cell with the type of
immunity with which it is most commonly associated:

NK Cell
CD8+ T Cell
Innate immunity
Adaptive immunity
Innate immunity
Adaptive immunity

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 16

Upon secretion, interleukin-12 and -18 (IL-12, IL-18) can potentially
stimulate NK and T cells to drive production of which interferon?

Correct Incorrect
The correct answer is C

IL-12/-18 induce production of IFN-γ, which plays
a pivotal role in host anti-tumor immunity

Next

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 17

Interferon-γ can have a variety of anti-tumor benefits
that include which of the following?

Correct Incorrect
The correct answer is A

Not only does Interferon-γ play a role in directly
killing tumor cells, it also can increase antigen
processing machinery, decrease the remodeling
of extracellular matrix, and inhibit angiogenesis.

Next

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 18

Match the cell type and cytokine with the type of
cancer-immunity processes with which it is primarily associated:

Anti-tumor immunity
Drag cell type and cytokine here
Both anti-tumor immunity
AND tumor-induced
immunosuppression
Drag cell type and cytokine here
Tumor-induced
immunosuppression
Drag cell type and cytokine here
IL-6
IL-18
TNF-α
TGF-β
CD8+ T cells
NK cells
HD-IL-2
IL-12
Mature-DC
Treg cells
MDSCs
VEGF
IL-10
IL-6
IL-18
TNF-α
TGF-β
CD8+ T cells
NK cells
HD-IL-2
IL-12
Mature-DC
Treg cells
MDSCs
VEGF
IL-10

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 19
Cytokines are proteins made in response to pathogens
and other antigens that regulate and mediate
inflammatory and immune responses.
Correct Incorrect
The correct answer is True
The cytokine superfamily of proteins is an integral
part of the signaling network between cells and is
essential in generating and regulating the immune
system. Cytokines influence growth and
development, hematopoiesis, lymphocyte
recruitment, T-cell subset differentiation,
inflammation, and anti-tumor effects. Hundreds
of cytokines have been identified.
Next

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 20
Interleukin-2 (IL-2) is a cytokine that stimulates the activation
and expansion of anti-tumor CD8+ T cells.
Correct Incorrect
The correct answer is True

Interleukin-2 (IL-2) can stimulate the expansion and
activation of CD8+ T cells. In addition, IL-2 can
expand and activate natural killer (NK)
and regulatory T (Treg) cells.

Next

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 21

Binding of IL-2 to the intermediate-affinity 2-chain
IL-2 receptor would be expected to:

Correct Incorrect
The correct answer is B

Because CD8+ T cells and natural killer cells express
the intermediate-affinity 2-chain
IL-2 receptor, binding of IL-2 to this receptor would
induce the proliferation of these cells and the killing
of target cells, thereby stimulating the anti-tumor
effects of IL-2.

Next

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

Question 22

The effects of the PD-1/PD-L1 pathway on the immune system are:

Correct Incorrect
The correct answer is B

When the PD-1/PD-L1 pathway is activated, the
immune system is suppressed; therefore, the immune
system is unable to mount an
anti-tumor response.

Next

Mural Oncology is a trademark of Mural Oncology, plc.
© 2023 Mural Oncology, plc. All rights reserved.

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